期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 47, 期 9, 页码 2990-2992出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.47.9.2990-2992.2003
关键词
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We isolated mutant YM644, which showed elevated resistance to norfloxacin, ethidium bromide, acriflavine, and rhodamine 6G, from Pseudomonas aeruginosa YM64, a strain that lacks four major multidrug efflux pumps. The genes responsible for the resistance were mexHI-opmD. Elevated ethidium extrusion was observed with cells of YM644 and YM64 harboring a plasmid carrying the genes. Disruption of the genes in the chromosomal DNA of YM644 made the cells sensitive to the drugs.
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