期刊
JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE
卷 50, 期 7, 页码 333-338出版社
BLACKWELL VERLAG GMBH
DOI: 10.1046/j.1439-0442.2003.00549.x
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HyLine Brown laying hens at 30 weeks of age were treated twice daily with Fadrozole, a non-steroidal aromatase inhibitor (AI; 1 mg/kg body weight; i.m.) for six consecutive days; control hens received saline. Blood was collected every day 0.5 h after oviposition, i.e. just before AI treatment. Ovarian steroids: progesterone (P-4), testosterone (T) and estradiol (E-2), and iodothyronines: thyroxine (T-4), triiodothyronine (T-3) and reverse-triiodothyronine (rT(3)) were measured in blood plasma by radioimmunoassay methods. In AI-treated hens a gradual delay in oviposition time was observed. AI significantly decreased P-4 and E-2 levels, maximally by 43% on day 4 and by 74% on day 5, respectively, and elevated T level, maximally by 248% on day 4. Simultaneously, the increases in T-4 and T-3 levels with no changes in rT(3) levels were observed. The maximal effect of AI on T-4 and T-3 levels was found on day 4 (60% increase) and day 5 ( 312% increase), respectively. Moreover, statistically significant, negative coefficient of correlation between E-2 and T-3 (r = -0.51), and positive coefficient of correlation between T and T-3 (r = 0.42) in AI-treated hens were found. The results obtained indicate that in mature laying hens there is a strong relationship between ovarian steroids and thyroid hormones, and suppression of E-2 synthesis not only disrupts ovarian function but also affects the activity of the thyroid gland and peripheral metabolism of thyroid hormones.
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