期刊
ARCHIVES OF ORAL BIOLOGY
卷 58, 期 10, 页码 1309-1317出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.archoralbio.2013.07.005
关键词
Curcumin; Innate immunity; Cell signalling; Cytokines; NF-kappa B; MAPK; SOCS
资金
- National Council for Scientific and Technological Development (CNPq)
- Brazilian Ministry of Science
- Coordination for Improvement of Higher Education Personnel (CAPES) [4638-05]
- Brazilian Ministry of Education. National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH) [1R01DE018290, P30GM103331-02]
Curcumin is the active compound in the extract of Curcuma longa rhizomes with anti-inflammatory properties mediated by inhibition of intracellular signalling. SOCS and MAP-Kinases are involved in the signalling events controlling the expression of IL-6, TNF-alpha and PGE(2), which have important roles on chronic inflammatory diseases. The aim was to assess if these pathways are involved in curcumin-mediated effects on LPS-induced expression of these cytokines in macrophages. RAW 264.7 murine macrophages were stimulated with Escherichia coli LPS in the presence and absence of non-cytotoxic concentrations of curcumin. Curcumin potently inhibited LPS-induced expression of IL-6, TNF-alpha and COX-2 mRNA and prevented LPS-induced inhibition of SOCS-1 and -3 expression and the inhibition of the activation of p38 MAPKinase by modulation of its nuclear translocation. In conclusion, curcumin potently inhibits expression of LPS-induced inflammatory cytokines in macrophages via mechanisms that involve modulation of expression and activity of SOCS-1 and SOCS-3 and of p38 MAPK. (C) 2013 Elsevier Ltd. All rights reserved.
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