期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 24, 期 9, 页码 486-492出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0165-6147(03)00232-3
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资金
- NIMH NIH HHS [P50 MH068789, R01 MH63271, P50 MH44866, R01 MH063271] Funding Source: Medline
Abnormal activity of the dopamine system has been implicated in several psychiatric and neurological illnesses; however, lack of knowledge about the precise sites of dopamine dysfunction has compromised our ability to improve the efficacy and safety of dopamine-related drugs used in treatment modalities. Recent work suggests that dopamine transmission is regulated via the concerted efforts of a cohort of cytoskeletal, adaptor and signaling proteins called dopamine receptor-interacting proteins (DRIPs). The discovery that two DRIPs, calcyon and neuronal Ca2+ sensor 1 (NCS-1), are upregulated in schizophrenia highlights the possibility that altered protein interactions and defects in Ca2+ homeostasis might contribute to abnormalities in the brain dopamine system in neuropsychiatric diseases.
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