期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 47, 期 9, 页码 3005-3007出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.47.9.3005-3007.2003
关键词
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Poly(lactide-co-glycolide) (PLG) microspheres (diameter, less than 3 mum) containing isoniazid, rifampin, and pyrazinamide were used in a sustained oral drug delivery system to treat murine tuberculosis. Drug levels above the MIC were observed up to 72 h in plasma and for 9 days in various organs. Relative bioavailability of encapsulated drugs was greater than that of free drugs. Chemotherapy results showed better or equivalent clearance of bacilli in the PLG-drug-administered group (weekly) than with free drugs (daily).
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