期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 38, 期 9, 页码 811-824出版社
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0223-5234(03)00144-2
关键词
substituted benzimidazole styryl sulfones; MAP kinase inhibitors; anti-cancer activity
New styryl sulfone compounds have been synthesized and evaluated for their anti-proliferative activity. Among the compounds synthesized, one compound (7k) has shown 51% tumor growth inhibition in mice implanted with HT-29 human carcinoma at 400 mg kg(-1) orally. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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