期刊
ARCHIVES OF OPHTHALMOLOGY
卷 130, 期 1, 页码 90-100出版社
AMER MEDICAL ASSOC
DOI: 10.1001/archophthalmol.2011.364
关键词
-
资金
- Sjogren's Syndrome Foundation
- National Institutes of Health [EY20889]
- NATIONAL EYE INSTITUTE [R01EY020889] Funding Source: NIH RePORTER
Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by symptoms of dryness and irritation. Although the pathogenesis of dry eye disease is not fully understood, it is recognized that inflammation has a prominent role in the development and propagation of this debilitating condition. Factors that adversely affect tear film stability and osmolarity can induce ocular surface damage and initiate an inflammatory cascade that generates innate and adaptive immune responses. These immunoinflammatory responses lead to further ocular surface damage and the development of a self-perpetuating inflammatory cycle. Herein, we review the fundamental links between inflammation and dry eye disease and discuss the clinical implications of inflammation in disease management. Arch Ophthalmol. 2012; 130(1):90-100
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据