期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 8, 期 -, 页码 D1219-D1226出版社
BIOSCIENCE RESEARCH INST-BRI
DOI: 10.2741/1117
关键词
FAK; PYK2; osteoclasts; integrins; signaling; review
资金
- NIAMS NIH HHS [P30AR46031, AR48120, AR47830] Funding Source: Medline
Integrin alpha(v)beta(3) plays a pivotal role in osteoclastic bone resoprtion by mediating both osteoclast attachments on bone matrix and cytoskeleton reorganization. The focal adhesion kinase (FAK) family kinases including FAK and proline-rich tyrosine kinase 2 (PYK2) are major tyrosine kinases activated by integrin engagement. In osteoclasts, although FAK is expressed, PYK2 appears to be the predominant mediator of integrin alphavbeta3 signaling events that influence osteoclast physiology and pathology. Recent progress in the understanding of the role of PYK2/FAK kinases in the regulation of osteoclastic actin cytoskeletal organization, cell migration, and bone resorption will be discussed in this review.
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