期刊
JOURNAL OF PINEAL RESEARCH
卷 35, 期 2, 页码 98-103出版社
WILEY
DOI: 10.1034/j.1600-079X.2003.00058.x
关键词
Alzheimer's disease; amyloid; free radicals; melatonin; metal ions
Alzheimer's disease, among other pathological features, is characterized by an over-accumulation of amyloid-beta peptide, metal ions, and oxidative stress proteins in the brain. Amyloid-beta aggregated peptides with bound metal ions may initiate free radical generation with consequent protein and lipid oxidation, reactive oxygen species formation and eventually neuronal death. Melatonin is able to dramatically reduce the free radical formation which follows the interaction between transition metal ions and amyloid-beta . This paper reports the scavenging effect of melatonin of reactants generated by amyloid peptides in combination with some metal ions.
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