期刊
VACCINE
卷 21, 期 25-26, 页码 3542-3549出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(03)00407-9
关键词
antipertussis antibodies; susceptibility; Bordetella pertussis
资金
- NIAID NIH HHS [N01-AI-15125] Funding Source: Medline
Prospectively collected data in a Swedish vaccine efficacy trial were used to investigate transmission of pertussis from small study infants to other household members. Forty one percent (258/627) of the exposed persons with paired serology had laboratory confirmed pertussis. The majority of those with laboratory confirmed pertussis had less than 14 days of cough and many were asymptomatic. High susceptibility to symptomatic pertussis was found among persons with low initial IgG antibody concentrations against pertussis toxin, especially those without previous history of pertussis vaccination or disease. (C) 2003 Elsevier Ltd. All rights reserved.
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