期刊
IMMUNOLOGY LETTERS
卷 88, 期 3, 页码 221-226出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-2478(03)00080-4
关键词
Th1/Th2 balance; NT-3; TrkC; IL-4; IFN-gamma
类别
Neurotrophins, including nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 (NT-3) are essential factors for the development of the nervous system. In this report, we demonstrate gene expression of neurotrophins and their receptors in T helper 1 (Th1) and T helper 2 (Th2) cells induced from naive CD4(+) CD45RB(+) T cells of ovalbumin-specific DO11.10 T cell receptor transgenic mice. Interestingly, the TrkC gene, which encodes a high affinity receptor for NT-3, was expressed in Th2 cells, but not in Th1 and naive CD4(+) T cells. Expression of the TrkC gene was markedly augmented by addition of anti-IFN-gamma monoclonal antibody (mAb) into the culture, whereas it was blocked by anti-IL-4 mAb. Moreover, NT-3 synergistically enhanced anti-CD3 mAb-induced IL-4 production by Th2 cells, but did not affect IFN-gamma production by Th1 cells. These data suggest that NT-3, through its receptor TrkC, plays a critical role in regulating the Th1/Th2 balance. (C) 2003 Elsevier B.V. All rights reserved.
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