期刊
VACCINE
卷 21, 期 25-26, 页码 3629-3637出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(03)00408-0
关键词
influenza vaccine; MF59 adjuvant; immunogenicity; HIV; highly active antiretroviral therapy; HAART; CD4+T lymphocytes; HIV-1 RNA
Objective: To Study immunological and virological parameters in HIV-1-seropositivc adults treated with highly active antiretroviral therapy (HAART) for at least 7 months after immunisation with MF59-adjuvanted (FLUAD, Chiron, Siena, Italy) or with non-adjuvanted (AGRIPPAL, Chiron) trivalent influenza vaccine. Design: Blood samples, collected before and after vaccination, were analysed for the presence of antibodies against the vaccine antigens, for number of CD4+ T lymphocytes and HIV-1 RNA levels. Results: Forty-four volunteers received FLUAD and 40 AGRIPPAL influenza vaccine. Thirty days after vaccination both adjuvanted and non-adjuvanted vaccines induced significant increases of anti-influenza virus antibodies. However, antibody titres found in Volunteers receiving adjuvanted vaccine were in general significantly higher when compared with those found in the non-adjuvanted vaccine group. The requirements of the European Commission of influenza vaccine for a non-elderly adult Population were always met by recipients of the adjuvanted vaccine, even in those with the lowest CD4+ cell counts (<200 cells/mmc). The subjects receiving the non-adjuvanted vaccine failed to met these requirements. The CD4+ T lymphocytes and plasma HIV-1 RNA levels remained stable in the long term. both in people receiving adjuvanted or non-adjuvanted vaccine. Conclusion: MF59-adjuvanted influenza induced a significant higher immune responses as compared with conventional vaccine in HIV-seropositive HAART-treated patients. Both vaccines were safe regarding HIV RNA viral replication and loss of CD4+ T lymphocytes. (C) 2003 Elsevier Science Ltd. All rights reserved.
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