期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 51, 期 19, 页码 5677-5679出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf0302714
关键词
Lupinus argenteus; leguminosae; isoflavones; linolenic acid; antibacterial; potentiation; MDR pump; Staphylococcus aureus
资金
- NIGMS NIH HHS [GM 49631, R01 GM 59903] Funding Source: Medline
Isoflavones isolated from Lupinus argenteus were found to potentiate the antibacterial activity of alpha-linolenic acid, also found in the same plant. The isoflavones also potentiated the activity of the natural plant antibiotic berberine and the synthetic fluoroquinoline antibiotic norfloxacin. The isoflavones increased the uptake of berberine into Staphylococcus aureus cells, indicating that they may be inhibiting a multidrug resistance pump (MDR). Thus, L. argenteus contains a weak antibacterial and also MDR pump inhibitors, which increase its potency.
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