期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 19, 页码 4104-4112出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm020477g
关键词
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A series of 5-benylidene-1,2-dihydrochromeno[3,4-f]quinolines (4) were synthesized and tested in bioassays to evaluate their progestational activities, receptor- and tissue-selectivity profiles as selective progesterone receptor modulators (SPRMs). Most of the new analogues exhibited as highly potent progestins with more than 100-fold receptor selectivity over other steroid hormone receptors and LG120920 (7b) demonstrated tissue selectivity toward uterus and vagina versus breasts in a rodent model after oral administration.
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