期刊
NEUROSCIENCE LETTERS
卷 348, 期 2, 页码 81-84出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(03)00721-3
关键词
astrocytes; glutamate; glycolysis; lactate; oxidative phosphorylation
Microenvironmental changes including elevated levels Of L-glutamate, ionic homeostasis, acidification, and oxygen level are associated with brain insults. Their effects on energy metabolism were studied in cultured astrocytes. L-Glutamate caused a decrease in lactate accumulation through the activation of transporter in astrocytes in a concentration- and time-dependent manner. Decreases in glucose uptake, lactate synthesis and accumulation as well as increases in mitochondrial activity indicated a switch of the astrocytic metabolism from glycolytic to oxidative. Environmental changes co-operated with L-glutamate to regulate the metabolic strategy, e.g. KCl and oxygen deprivation reversed but acidification exacerbated the L-glutamate- mediated decrease in lactate accumulation. Taken together, during chronic exposure, oxidation of non-glucose substrates such as L-glutamate fuels the active transport of L-glutamate into astrocytes. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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