期刊
SCIENCE
卷 301, 期 5639, 页码 1527-1530出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1087785
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资金
- NIAID NIH HHS [AI 47868, AI 07118, AI 22553] Funding Source: Medline
- NIAMS NIH HHS [AR 40312] Funding Source: Medline
Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression pro. ling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in de. ning clinical forms of disease and providing insights into the regulation of immune responses to pathogens.
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