期刊
BIOCHEMICAL JOURNAL
卷 374, 期 -, 页码 607-611出版社
PORTLAND PRESS
DOI: 10.1042/BJ20030995
关键词
mitochondrial carrier family; mitochondrial pyruvate transport; pyruvate metabolism; Saccharomyces
Mitochondrial pyrurvarte transport is fundamental for metabolism and mediated by a specific inhibitable carrier. We have identified the yeast mitochondrial pyruvate carrier by measuring inhibitor-sensitive pyruvate uptake into mitochondria from 18 different Saccharomyces cerevisiae mutants, each lacking an unattributed member of the mitochondrial carrier family (MCF). Only mitochondria from the YIL006w deletion mutant exhibited no inhibitor-sensitive pyruvate transport, but otherwise behaved normally. YIL006w encodes a 41.9 kDa MCF member with homologous proteins present in both the human and Mouse genomes.
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