期刊
BRITISH JOURNAL OF CANCER
卷 89, 期 6, 页码 968-970出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6601232
关键词
docetaxel; calcitriol; vitamin D; prostate cancer; chemotherapy
类别
资金
- NCRR NIH HHS [M01 RR000334, 3M01RR00334-33S2] Funding Source: Medline
Intermittent use of chemotherapy for androgen-independent prostate cancer ( AIPC) instead of treatment until disease progression may reduce toxicity. We prospectively tested this approach in eight AIPC patients responding to calcitriol plus docetaxel who reached a serum prostate-specific antigen (PSA) <4 ng ml(-1). Chemotherapy was suspended until a rise in PSA ≥50% and 1 ng ml(-1). The median duration of treatment holiday was 20 weeks (13 - 43+ weeks) and all patients retained sensitivity to re-treatment. Chemotherapy holiday was associated with an improvement of fatigue ( P = 0.05). Intermittent chemotherapy for AIPC is feasible and deserves further study.
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