期刊
CLINICAL INFECTIOUS DISEASES
卷 37, 期 6, 页码 752-760出版社
UNIV CHICAGO PRESS
DOI: 10.1086/377539
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Levofloxacin demonstrates concentration-dependent bactericidal activity most closely related to the pharmacodynamic parameters of the ratio of area under the concentration-time curve (AUC) to minimum inhibitory concentration (MIC) and the ratio of peak plasma concentration (C-max) to MIC. Increasing the dose of levofloxacin to 750 mg exploits these parameters by increasing peak drug concentrations, allowing for a shorter course of treatment without diminishing therapeutic benefit. This was demonstrated in a multicenter, randomized, double-blind investigation that compared levofloxacin dosages of 750 mg per day for 5 days with 500 mg per day for 10 days for the treatment of mild to severe community-acquired pneumonia ( CAP). In the clinically evaluable population, the clinical success rates were 92.4% ( 183 of 198 persons) for the 750-mg group and 91.1% ( 175 of 192 persons) for the 500-mg group (95% confidence interval, - 7.0 to 4.4). Microbiologic eradication rates were 93.2% and 92.4% in the 750-mg and 500-mg groups, respectively. These data demonstrate that 750 mg of levofloxacin per day for 5 days is at least as effective as 500 mg per day for 10 days for treatment of mild-to-severe CAP.
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