期刊
JOURNAL OF CELL BIOLOGY
卷 162, 期 6, 页码 1149-1160出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200305018
关键词
axon; node of Ranvier; myelin; cell adhesion; Schwann cell
类别
资金
- NINDS NIH HHS [NS17965, R01 NS017965] Funding Source: Medline
- PHS HHS [R01-23375] Funding Source: Medline
In myelinated axons, K+ channels are concealed under the myelin sheath in the juxtaparanodal region, where they are associated with Caspr2, a member of the neurexin superfamily. Deletion of Caspr2 in mice by gene targeting revealed that it is required to maintain K+ channels at this location. Furthermore, we show that the localization of Caspr2 and clustering of K channels at the juxtaparanodal region depends on the presence of TAG-1, an immunoglobulin-like cell adhesion molecule that binds Caspr2. These results demonstrate that Caspr2 and TAG-1 form a scaffold that is necessary to maintain K+ channels at the juxtaparanodal region, suggesting that axon-glia interactions mediated by these proteins allow myelinating glial cells to organize ion channels in the underlying axonal membrane.
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