期刊
JOURNAL OF CELL BIOLOGY
卷 162, 期 6, 页码 1123-1133出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200302090
关键词
apoptosis; matrix metalloproteinases; stromal-epithelial interaction; terminal end bud; tissue inhibitor of metalloproteinases
类别
资金
- NCI NIH HHS [CA58207, CA57621, R01 CA057621, P50 CA058207] Funding Source: Medline
During puberty, mouse mammary epithelial ducts invade the stromal mammary fat pad in a wave of branching morphogenesis to form a complex ductal tree. Using pharmacologic and genetic approaches, we find that mammary gland branching morphogenesis requires transient matrix metalloproteinase (MMP) activity for invasion and branch point selection. MMP-2, but not MMP-9, facilitates terminal end bud invasion by inhibiting epithelial cell apoptosis at the start of puberty. Unexpectedly, MMP-2 also represses precocious lateral branching during mid-puberty. In contrast, MMP-3 induces secondary and tertiary lateral branching of ducts during mid-puberty and early pregnancy. Nevertheless, the mammary gland is able to develop lactational competence in MMP mutant mice. Thus, specific MMPs refine the mammary branching pattern by distinct mechanisms during mammary gland branching morphogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据