期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 125, 期 37, 页码 11253-11258出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja0351692
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资金
- NIGMS NIH HHS [GM 46059] Funding Source: Medline
A dramatic acceleration of the enantioselective copper-catalyzed conjugate reduction of alpha,beta-unsaturated lactones, lactams, and esters is reported upon addition of alcohol additives. Good to excellent yields and enantioselectivities were realized using a catalyst generated in situ from CuCl2.H2O, t-BuONa, p-tol-BINAP, and PIMHS, and this methodology was applied to the synthesis of (-)-Paroxetine.
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