期刊
ARCHIVES OF NEUROLOGY
卷 68, 期 9, 页码 1131-1136出版社
AMER MEDICAL ASSOC
DOI: 10.1001/archneurol.2011.108
关键词
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资金
- Cephalon, Inc
- Allon Pharmaceuticals
- Elan Pharmaceutical
- Forest Laboratories
- National Institute of Health [R01-AG11378, P50-AG16574, U01-AG06786, AG11378]
- National Institute on Aging [R01-AG11378, P50-AG16574, P50 AG16574, U01 AG06786, RO1 AG32306, U01 AG024904-01]
- Robert H. Smith Family Foundation
- Center for Inherited Disease Research [U24 AG026395]
- Mayo Foundation
- Mayo Clinic Department of Psychiatry and Psychology
Objective: To examine default mode and salience network functional connectivity as a function of APOE epsilon 4 status in a group of cognitively normal age-, sex-, and education-matched older adults. Design: Case-control study. Subjects: Fifty-six cognitively normal APOE epsilon 4 carriers and 56 age-, sex- and education-matched cognitively normal APOE epsilon 4 noncarriers. Main Outcome Measure: Alterations in in-phase default mode and salience network connectivity in APOE epsilon 4 carriers compared with APOE epsilon 4 noncarriers ranging from 63 to 91 years of age. Results: A posterior cingulate seed revealed decreased in-phase connectivity in regions of the posterior default mode network that included the left inferior parietal lobe, left middle temporal gyrus, and bilateral anterior temporal lobes in the epsilon 4 carriers relative to APOE epsilon 4 noncarriers. An anterior cingulate seed showed greater in-phase connectivity in the salience network including the cingulate gyrus, medial prefrontal cortex, bilateral insular cortex, striatum, and thalamus in APOE epsilon 4 carriers vs noncarriers. There were no groupwise differences in brain anatomy. Conclusions: The observation of functional alterations in default mode and salience network connectivity in the absence of structural changes between APOE epsilon 4 carriers and noncarriers suggests that alterations in connectivity may have the potential to serve as an early biomarker.
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