期刊
NEUROSCIENCE LETTERS
卷 349, 期 1, 页码 37-40出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(03)00700-6
关键词
excitotoxicity; phosphorylation; protein expression; N-methyl-D-aspartate receptors; spinal cord injury; quisqualate
资金
- NIDA NIH HHS [DA13166] Funding Source: Medline
- NINDS NIH HHS [NS40096] Funding Source: Medline
The role of NMDA receptor expression and post-translational modification in the pathological and behavioral consequences Of injury were examined in rats receiving spinal injections of quisqualate. Spinal cords were removed 3 days following the development of excessive gooming behavior or. if the spontaneous pain-like behavior was not observed, 13 days following injections. Western blots from the spinal tissue demonstrated that non-grooming animals had elevated protein levels of the NR1 subunit of the NMDA receptor. These subunits did not demonstrate an enhanced level of phosphorylation. NR1 protein in grooming rats was not elevated, but there was a significant increase in NR1 serine phosphorylation. These findings suggest that excitotoxic lesions of the spinal cord induce both NR1 expression and NR1 serine phosphorylation. However, the injury-induced excessive grooming behavior is only associated with phosphorylation of the NR1 subunit. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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