期刊
FEBS LETTERS
卷 552, 期 2-3, 页码 141-144出版社
WILEY
DOI: 10.1016/S0014-5793(03)00905-0
关键词
nitric oxide; nitric oxide synthase; artemisinin; parthenolide; malaria; NF-kB; IkB-alpha
Artemisinin is a natural product used as an alternative drug in the treatment of severe and multidrug-resistant malaria. In the present work we show that artemisinin shares with other sesquiterpene lactones the ability to inhibit the activation of the nuclear factor NF-kB: by this mechanism, artemisinin, as well as parthenolide, inhibits nitric oxide synthesis in cytokine-stimulated human astrocytoma T67 cells. These results suggest that artemisinin, in addition to its antiparasitic properties, could also exert a therapeutic effect on neurological complications of malaria. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据