期刊
FEMS MICROBIOLOGY LETTERS
卷 226, 期 2, 页码 267-271出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-1097(03)00615-3
关键词
coaggregation; dentilisin; fimbria; Porphyromonas gingivalis; Treponema denticola
类别
Treponema denticola has been reported to coaggregate with Porphyromonas gingivalis and localize closely together in matured subgingival plaque. In this study of the interaction of T denticola with P. gingivalis, the P. gingivalis fimbria-binding protein of T denticola was identified by two-dimensional electrophoresis followed by a ligand overlay assay with P. gingivalis fimbriae, and was determined to be dentilisin, a chymotrypsin-like proteinase of T denticola. The binding was further demonstrated with a ligand overlay assay using an isolated GST fusion dentilisin construct. Our results suggest that P. gingivalis fimbriae and T denticola dentilisin are implicated in the coaggregation of these bacteria. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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