期刊
JOURNAL OF CELL BIOLOGY
卷 162, 期 7, 页码 1255-1266出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200305055
关键词
organelle division; membrane fission; peroxisome assembly; peroxin; liposomes
类别
We describe an unusual mechanism for organelle division. In the yeast Yarrowia lipolytica, only mature peroxisomes contain the complete set of matrix proteins. These mature peroxisomes assemble from several immature peroxisomal vesicles in a multistep pathway. The stepwise import of distinct subsets of matrix proteins into different immature intermediates along the pathway causes the redistribution of a peroxisomal protein, acyl-CoA oxidase (Aox), from the matrix to the membrane. A significant redistribution of Aox occurs only in mature peroxisomes. Inside mature peroxisomes, the membrane-bound pool of Aox interacts with Pex16p, a membrane-associated protein that negatively regulates the division of early intermediates in the pathway. This interaction inhibits the negative action of Pex-16p, thereby allowing mature peroxisomes to divide.
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