Experimental studies of adult Drosophila chemosensory behaviour

Drosophila melanogaster is a powerful animal model to study the processes underlying behavioural responses to chemical cues. This paper provides a review of the important literature to present recent advances in our understanding of how gustatory and olfactory stimuli are perceived. An overview is given of the experimental procedures currently used to characterize the fly chemosensory behaviour. Since this species provides extremely useful genetic tools, a focus is made on those allowing to manipulate behaviour, and hence to understand its molecular and cellular bases. Such tools include single-gene mutants and the Gal4/UAS system. They can be combined with studies of the natural polymorphism of behavioural responses. Recent data obtained with these various approaches unravel some important aspects of taste and olfaction. These appear as rather complex processes, as revealed by results showing dose-dependence, plasticity and sexual dimorphism. Taken together, these results and the available tools open interesting perspectives for the years to come, in our attempts to make the link between genes and behaviour. (C) 2003 Elsevier B.V. All rights reserved.