Prospects for Minocycline Neuroprotection

Minocycline is a clinically available antibiotic and anti-inflammatory drug that also demonstrates neuroprotective properties in a variety of experimental models of neurological diseases. There have thus far been more than 300 publications on minocycline neuroprotection, including a growing number of human studies. Our objective is to critically review the biological basis and translational potential of this action of minocycline on the nervous system. Arch Neurol. 2010;67(12):1442-1448. Published online August 9, 2010. doi:10.1001/archneurol.2010.191