期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 7, 期 5, 页码 534-539出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.cbpa.2003.08.002
关键词
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资金
- NIGMS NIH HHS [GM 62120, R01 GM062120-07] Funding Source: Medline
The proteasome plays a role in a myriad of intracellular processes from cell-cycle control to antigen presentation. Central to these processes is the targeting of selected proteins for proteasomal degradation via their conjugation to ubiquitin. The mechanisms by which the ubiquitin-dependent proteasomal proteolysis occurs can be divided into four steps: first, substrate protein recognition by its cognate E3 ubiquitin ligase; second, polyubiquitinated protein substrate recruitment to the proteasome; third, protein substrate deubiquitination; and four, proteolytic chamber pore opening/substrate translocation followed by proteolysis. Recent advances include the identification of novel E3 ubiquitin ligase recognition determinants, a new isopeptidase activity, and a better understanding of how the proteasome's axial channels are gated.
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