期刊
MEMORIAS DO INSTITUTO OSWALDO CRUZ
卷 98, 期 7, 页码 959-961出版社
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762003000700017
关键词
Plumbago scandens; plumbagin; antimicrobial activity
Plumbagin is a naturally occurring naphthoquinone isolated from roots of Plumbago scandens. The plant was collected at the Campus of Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil. P. scandens is used as a traditional medicine for the treatment of several diseases. The antimicrobial activity of plumbagin was evaluated using the macrodilution method. The compound exhibited relatively specific activity against bacteria and yeast. The minimum inhibitory concentration test showed the growth inhibiton of Staphylococcus aureus at a concentration of 1.56 mug/ml and of Candida albicans at a concentration of 0.78 mug/ml. These results suggest the naphthoquinone plumbagin as a promising antimicrobial agent.
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