期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 7, 期 5, 页码 616-625出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.cbpa.2003.08.006
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资金
- NIGMS NIH HHS [GM 66047, GM 58867] Funding Source: Medline
Oligosaccharides transact information exchange at the cell surface and modulate the activities and distribution of proteins within cells. Recently, the ability to modify monosaccharicle structures within cellular glycans through metabolic processes has offered a new avenue for biological studies. The technique of metabolic oligosaccharide engineering has been used to disrupt glycan biosynthesis, chemically modify cell surfaces, probe metabolic flux inside cells, and to identify specific glycoprotein subtypes from the proteome.
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