期刊
COGNITIVE BRAIN RESEARCH
卷 17, 期 3, 页码 637-650出版社
ELSEVIER
DOI: 10.1016/S0926-6410(03)00188-5
关键词
P300; novelty P3; inverse problem; event related potential; electroencephalography
资金
- NIMH NIH HHS [MH19554, MH11751] Funding Source: Medline
Recent research indicates that novel stimuli elicit at least two distinct components, the Novelty P3 and the P300. The P300 is thought to be elicited when a context updating mechanism is activated by a wide class of deviant events. The functional significance of the Novelty P3 is uncertain. Identification of the generator sources of the two components could provide additional information about their functional significance. Previous localization efforts have yielded conflicting results. The present report demonstrates that the use of principal components analysis (PCA) results in better convergence with knowledge about functional neuroanatomy than did previous localization efforts. The results are also more convincing than that obtained by two alternative methods, MUSIC-RAP and the Minimum Norm. Source modeling on 129-channel data with BESA and BrainVoyager suggests the P300 has sources in the temporal-parietal junction whereas the Novelty P3 has sources in the anterior cingulate. (C) 2003 Elsevier B.V. All rights reserved.
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