期刊
JOURNAL OF NATURAL PRODUCTS
卷 66, 期 10, 页码 1299-1301出版社
AMER CHEMICAL SOC
DOI: 10.1021/np030233e
关键词
-
Bacterial strains CF-20 (CECT5719) and C-148 (CECT5718), isolated from cultures of larvae of molluscs, are shown to produce substances 1-5 with strong antibiotic activity against Vibrio anguillarum (MIC: 0.03-0.07 mug/mL) and identified as the DD-diketopiperazines cyclo(D)-Pro-(D)-Phe (1), cyclo(D)-Pro-(D)-Leu (2), cyclo(D)-Pro-(D)-Val (3), cyclo(D)-Pro-(D)-Ile (4), and cyclo-trans-4-OH-(D)-Pro-(D)-Phe (5). Comparison with other stereoisomers indicates that inhibition of V. anguillarum is associated with the presence of at least one D-amino acid in the diketopiperazine system. This is the first time a series of DD-diketopiperazines has been isolated from a single natural source and their inhibitory activity against V. anguillarum described.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据