期刊
JOURNAL OF DENTAL RESEARCH
卷 82, 期 10, 页码 844-848出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/154405910308201016
关键词
aging; reserve; saliva; parotid; submandibular/sublingual; xerostomia
资金
- NCRR NIH HHS [M01-RR00042] Funding Source: Medline
- NIDCR NIH HHS [DE07101, K23 DE00427] Funding Source: Medline
- BHP HRSA HHS [D31 AH90005] Funding Source: Medline
A loss of acinar cells occurs with aging, while salivary production remains age-stable in healthy adults. It is hypothesized that a secretory reserve exists to preserve function despite a loss of acinar cells in normal aging. The purpose of this double-blind, placebo-controlled, crossover study was to determine age-related differences in salivary response to an anti-sialogogue (glycopyrrolate). Thirty-six healthy subjects (18 young - 20-38 yrs; 18 older - 60-77 yrs) received 4.0 mug/kg IV glycopyrrolate. Parotid and submandibular/sublingual saliva samples and xerostomia questionnaire responses were collected. Variables calculated for each subject were: times to initial and maximum suppression and xerostomic, complaint; time to recovery; and durations of suppression and complaint. Salivary function was more adversely affected in older persons. There were no consistent age-associated questionnaire response differences. These findings suggest that salivary gland output is more adversely affected by an anti-sialogogue in healthy older vs. younger adults, supporting the secretory reserve hypothesis of salivary function.
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