期刊
ARCHIVES OF MICROBIOLOGY
卷 201, 期 1, 页码 61-66出版社
SPRINGER
DOI: 10.1007/s00203-018-1553-8
关键词
Bacteriocin CAMT2; Listeria monocytogenes; Cytoplasmic membrane damage; Mode of action
类别
资金
- Guangdong Provincial Key Laboratory of Aquatic Product Processing and safety [GDPKLAPPS1503]
- Department of Science and Technology of Guangdong Province [2016A020222014, 2014A020217018, 2014B020205005]
- Project of Enhancing Scool With Innovation of Guangdong Ocean University [GDOU2013050205, 2014050203]
Bacteriocin CAMT2, produced by Bacillus amyloliquefaciens ZJHD3-06, has been shown to exhibit protective activity against important food spoilage and food-borne bacterial pathogens. This study was conducted to investigate the mode of action of bacteriocin CAMT2 against highly pathogenic Listeria monocytogenes ATCC 19111. The addition of bacteriocin CAMT2 at 64AU/ml inhibited L. monocytogenes ATCC 19111. An efflux of K+ ions, lactic acid dehydrogenase and an increase in extracellular electrical conductivity was observed in CAMT2-treated L. monocytogenes. Electron microscopy showed morphological alterations such as uneven cell surface, accumulation of cell debris and bacterial lysis. These results show that bacteriocin CAMT2 inhibit L. monocytogenes by increasing cell permeability and inducing membrane damage, hence it has the great application potentials in ensuring food safety.
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