期刊
ARCHIVES OF MICROBIOLOGY
卷 195, 期 6, 页码 447-451出版社
SPRINGER
DOI: 10.1007/s00203-012-0864-4
关键词
Antibiotic resistance; Tetracycline; Newborn; Cesarean-section; Vaginal delivery
类别
资金
- University of Puerto Rico, The Puerto Rico Louis Strokes Alliance for Minority Participation and BioMinds
- UPR NIH SCoRE PES program
- Div Of Biological Infrastructure
- Direct For Biological Sciences [0959864] Funding Source: National Science Foundation
Newborns acquire their first microbiota at birth. Maternal vaginal or skin bacteria colonize newborns delivered vaginally or by C-section, respectively (Dominguez-Bello et al. 2010 #884). We aimed to determine differences in the presence of four tetracycline (tet) resistance genes, in the microbes of ten newborns and in the mouth and vagina of their mothers, at the time of birth. DNA was amplified by PCR with primers specific for [tet(M), tet(O), tet(Q), and tet(W)]. Maternal vaginas harbored all four tet resistance genes, but most commonly tet(M) and tet(O) (63 and 38 %, respectively). Genes coding for tet resistance differed by birth mode, with 50 % of vaginally delivered babies had tet(M) and tet(O) and 16 and 13 % of infants born by C-section had tet(O) and tet(W), respectively. Newborns acquire antibiotic resistance genes at birth, and the resistance gene profile varies by mode of delivery.
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