期刊
IMMUNITY
卷 19, 期 4, 页码 535-548出版社
CELL PRESS
DOI: 10.1016/S1074-7613(03)00268-1
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- NIAID NIH HHS [AI 36199, R01 AI036199] Funding Source: Medline
Effector CD4(+) T cells rapidly activate high-level cytokine expression following TCR stimulation. Consistent with accelerated protein production in these cells, global mRNA profiles revealed that, after cytokines, the most impressive cluster of activated genes encode rRNA-maturation factors. Activation of these genes was ERK-MAPK dependent, accompanied by increased rRNA transcription and faster maturation kinetics, and much greater in effector CD4(+) T cells than in naive cells. Ribosomal protein subunit (RPS) synthesis was also ERK-MAPK dependent and increased to match rRNA production, but without evident increase in RPS mRNA. Instead, stimulation promoted polysome loading of RPS mRNA via cis-acting, 5'-terminal oligopyrimidines. These results demonstrate how, in response to extracellular signals, effector CD4(+) T cells coordinately increase multiple ribosomal components to accommodate burgeoning cytokine production.
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