期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 13, 期 5, 页码 558-569出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2003.09.007
关键词
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Few biological macromolecular complexes exhibit the combination of massive size and hierarchical, symmetrical architecture embodied in icosahedral viruses. X-ray crystallography, electron cryomicroscopy and small-angle X-ray scattering provide complementary approaches to studying these remarkable structures. Through a combined approach, progress has been made towards providing detailed structures of highly complex and very large viruses, and towards imaging the dynamic structural changes performed by viruses at key stages in their life cycles.
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