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AMERICAN JOURNAL OF PSYCHIATRY
卷 160, 期 10, 页码 1887-1889出版社
AMER PSYCHIATRIC PRESS, INC
DOI: 10.1176/appi.ajp.160.10.1887
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Objective: Extracellular dopamine concentrations were estimated through measurement of [C-11]raclopride binding with positron emission tomography after dietary manipulation of the dopamine precursors tyrosine and phenylalanine. Method: Healthy male subjects were scanned on two occasions: once after receiving a balanced amino acid drink and once after receiving a drink mixture from which tyrosine and phenylalanine were omitted. Results: Dietary tyrosine and phenylalanine depletion increased [C-11]raclopride binding in the striatum by a mean of 6%. The change in [C-11]raclopride binding correlated significantly with the fall in the ratio of tyrosine and phenylalanine to large neutral amino acids. Conclusions: This is the first demonstration of an effect of a dietary manipulation on brain dopamine release in humans. This result provides support for the further investigation of the role of dietary manipulations in the treatment of neuropsychiatric disorders.
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