Insecticidal compounds against Drosophila melanogaster from Cornus officinalis Sieb. Et Zucc.

Dimethyl malate ( 1) and 5- hydroxymethyl furfural ( 2) were isolated as insecticidal compounds by bioassay-guided fractionation from MeOH extract of the fruits of Cornus officinalis Sieb. et Zucc. Insecticidal activity against larvae of D. melanogaster was demonstrated: 1 and 2 gave the LC50 value of 6.15 and 11.8 mumol/ mL of diet concentration, respectively. Acute toxicity against adults of D. melanogaster, 1 and 2 had the insecticidal activity, with the LD50 value of 21.5 and 34.0 mug/ adult.