期刊
ARCHIVES OF MEDICAL RESEARCH
卷 45, 期 7, 页码 525-539出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.arcmed.2014.10.008
关键词
Cervical cancer; Carcinogenesis; Signaling pathways; Inhibitors
资金
- Consejo Nacional de Ciencia y Tecnologia [CB-166808, CB-151493]
Cervical cancer is a public health issue in developing countries. Although the Pap smear and colposcopy remain the major strategies for detection, most cases are diagnosed in the late stages. Therefore, a major concern has been to develop early diagnostic approaches and more effective treatments. Molecular pathways that participate in cervical malignant transformation have emerged as promising directed therapeutic targets. In this review, we explore some of the major pathways implicated in cervical cancer development, including RAF/MEK/ERK, phosphatidylinositol-3 kinase (PI3K/AKT), Wnt/b-catenin, apoptosis and coupled membrane receptor signaling. We focus on the role of these pathways in cervical carcinogenesis, their alterations and the consequences of these abnormalities. In addition, the most recent preclinical and clinical data on the rationally designed target-based agents that are currently being tested against elements of these pathways are reviewed. (C) 2014 IMSS. Published by Elsevier Inc.
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