期刊
BEHAVIORAL NEUROSCIENCE
卷 117, 期 5, 页码 1006-1016出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.117.5.1006
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资金
- NHLBI NIH HHS [HL 65383, HL 36780] Funding Source: Medline
- NIA NIH HHS [AG 06088, AG 05131] Funding Source: Medline
- NICHD NIH HHS [P30 HD 03352] Funding Source: Medline
- NINDS NIH HHS [1F31 NS 42872] Funding Source: Medline
The hippocampus is important for the acquisition of new memories. It is also one of the few regions in the adult mammalian brain that can generate new nerve cells. The authors tested the hypothesis that voluntary exercise increases neurogenesis and enhances spatial learning in mice selectively bred for high levels of wheel running (S mice). Female S mice and outbred control (C) mice were housed with and without running wheels for 40 days. 5-Bromodeoxyuridine was used to label dividing cells. The Morris water maze was used to measure spatial learning. C runners showed a strong positive correlation between running distance and new cell number, as well as improved learning. In S runners, neurogenesis increased to high levels that reached a plateau, but no improvement in learning occurred. This is the first evidence that neurogenesis can occur without learning enhancement. The authors propose an alternative function of neurogenesis in the control of motor behavior.
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