期刊
GENE EXPRESSION PATTERNS
卷 3, 期 5, 页码 591-594出版社
ELSEVIER
DOI: 10.1016/S1567-133X(03)00119-4
关键词
ric-8; synembryn; mouse; cranial ganglia; dorsal root ganglia; sympathetic chain; neural tube; vomeronasal organ; cerebellum; hippocampus; neocortex; pineal gland
Recent biochemical studies revealed that ric-8A encodes a guanine nucleotide exchange factor for a subset of Got proteins. Ric-8 is a key component of a signaling network in C. elegans that regulates neurotransmitter secretion and also plays a role in centrosome-mediated events during early embryogenesis. Here we show that during the early development in mice (E9.5-E12.0) ric-8 (synembryn) is expressed in the developing nervous system such as the cranial ganglia, neural tube, sympathetic chain and dorsal root ganglia. Ric-8 is also found in the lens, vomeronasal organ, and endolymphatic sac. In adult brain, it is expressed in the neocortex, hippocampus, and cerebellum as well as in the pineal gland and ependymal layer. (C) 2003 Elsevier B.V. All rights reserved.
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