期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 252, 期 1-2, 页码 125-132出版社
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1025599126840
关键词
brush border membrane fluidity; oxidative damage; non-enzymatic glycation; diabetes mellitus; alkaline phosphatase; gamma-glutamyl transpeptidase
类别
The physical state (fluidity) of lipids modulates the activities of several membrane bound enzymes and transport proteins. Alteration of brush border membrane (BBM) fluidity is one of the several changes exhibited by the small intestine during diabetes. In the present study, an investigation of the diabetes induced regional changes in fluidity, oxidative damage, non-enzymatic glycation as well as the activities and the kinetic parameters of the enzymes alkaline phosphatase and gamma-glutamyl transpeptidase was carried out on the intestinal BBM. At the end of 6 weeks of diabetes, significant increases in the extent of both oxidative damage and non-enzymatic glycation were observed along the length of the intestine along with a simultaneous decrease in membrane fluidity. A significant correlation between the decrease in BBM fluidity and increase in non-enzymatic glycation was observed in the duodenum and jejunum. Additionally regional variations in the activities and kinetic parameters of both the enzymes were observed.
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