期刊
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
卷 1, 期 10, 页码 2112-2118出版社
WILEY
DOI: 10.1046/j.1538-7836.2003.00345.x
关键词
endothelium; glutathione; nitric oxide; nitric oxide synthase; reactive oxygen species; superoxide
资金
- NHLBI NIH HHS [HL 58976, HL 61828] Funding Source: Medline
Nitric oxide is a highly versatile heterodiatomic molecule that effects a variety of actions in the vasculture. Originally identified as a principal determinant of vascular tone, nitric oxide has since been recognized to exert antithrombotic, anti proliferative, and anti-inflammatory effects in the vasculture. At higher concentrations and in the setting of other oxidants, nitric oxide can promote vascular pathology. In this review, we summarize the molecular mechanisms of nitric oxide's actions in vascular biology and pathology.
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