期刊
MAGNETIC RESONANCE IN MEDICINE
卷 50, 期 4, 页码 749-757出版社
WILEY
DOI: 10.1002/mrm.10606
关键词
brain development; developmental imaging; children; pediatric brain data; structural MRI
资金
- NICHD NIH HHS [R01-HD37578-01, R01 HD038578-05] Funding Source: Medline
Spatial normalization and morphological studies of pediatric brain imaging data based on adult reference data may not be appropriate due to the developmental differences between the two populations. In this study, we set out to create pediatric templates and a priori brain tissue data from a large collection of normal, healthy children to compare it to standard adult data available within a widely used imaging software solution (SPM99, WDOCN, London, UK). Employing four different processing strategies, we found considerable differences between our pediatric data and the adult data. We conclude that caution should be used when analyzing pediatric brain data using adult a priori information. To assess the effects of using pediatric a priori brain information, the data obtained in this study is available to the scientific community from our website (www.irc.cchmc.org). (C) 2003 Wiley-Liss, Inc.
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