期刊
NATURE CELL BIOLOGY
卷 5, 期 10, 页码 869-878出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1045
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Eph receptors and their membrane-associated ephrin ligands mediate cell - cell repulsion to guide migrating cells and axons. Repulsion requires that the ligand - receptor complex be removed from the cell surface, for example by proteolytic processing of the ephrin ectodomain. Here we show that cell contact-induced EphB - ephrinB complexes are rapidly endocytosed during the retraction of cells and neuronal growth cones. Endocytosis occurs in a bi-directional manner that comprises of full-length receptor and ligand complexes. Endocytosis is sufficient to promote cell detachment and seems necessary for axon withdrawal during growth cone collapse. Here, we show a mechanism for the termination of adhesion and the promotion of cell repulsion after intercellular ( trans) interaction between two transmembrane proteins.
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