期刊
TETRAHEDRON
卷 59, 期 41, 页码 8219-8226出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2003.08.028
关键词
phospholenes; epoxides; enantioselective rearrangement
Cinchona alkaloids serve as effective chiral bases for enantioselective rearrangement of 3,4-epoxyphospholane oxides resulting in the formation of P,C-chirogenic 4-hydroxy-2-phospholene derivatives with up to 52% ee. A stereochemical course of the epoxide rearrangement involving anti beta-proton abstraction is proposed. 3,4-Epoxy-1-phospholane-borane rearranges to 4-hydroxy-2-phospholene-borane of 55% ee on treatment with sec-BuLi/sparteine base system. (C) 2003 Elsevier Ltd. All rights reserved.
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