A sequential tetra-n-propylammonium perruthenate (TPAP) -: Wittig oxidation olefination protocol

A convenient sequential oxidation-olefination protocol is reported using tetra-n-propylammonium perruthenate (TPAP) as oxidant and phosphonium salts as olefin source. The oxidation reaction mixture is added directly to the phosphorane facilitating an efficient method for this transformation that avoids work-up of potentially sensitive aldehyde intermediates. (C) 2003 Elsevier Ltd. All rights reserved.